منابع مشابه
The role of microRNA in acute/chronic, myeloid/lymphocytic leukemia
MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...
متن کاملIntermediate dose methotrexate (IDM) in childhood acute lymphocytic leukemia (ALL).
We employed three courses of intermediate dose Methotrexate (IDM) added onto a standard induction and maintenance program with the concept of both central nervous system (CNS) prophylaxis and simultaneous systemic intensification. Cranial radiation (RT) was not employed as CNS prophylaxis. Fifty of 52 patients (to age 18) achieved complete remission. Time on study now ranges from 22-68 months w...
متن کاملSerum vitamin A status in acute lymphocytic leukemia of childhood.
Serum vitamin A status was assessed at the diagnosis in 31 children with common acute lymphocytic leukemia (CALL) and seven with T-cell leukemia (T-ALL). A control population consisting of 22 children was established to serve as one basis for comparison. Mean concentrations of vitamin A, retinol-binding protein (RBP) and prealbumin (PA) were significantly less (p less than 0.01) in the sera of ...
متن کاملIntractable epilepsy in patients treated for childhood acute lymphocytic leukemia
PURPOSE In the 1970s and 80s, standard treatment for childhood acute lymphocytic leukemia (ALL) included both intrathecal methotrexate and whole-brain irradiation. During acute treatment, seizures were not uncommon. The development of intractable epilepsy years after treatment, however, has not been well described in the literature. We describe five patients who were treated for acute lymphocyt...
متن کاملGlucocorticoid receptors in subpopulations of childhood acute lymphocytic leukemia.
these patients, in general, have a more aggressive form of disease (2, 28, 29). Most patients have lymphoblasts that lack identifiable surface markers. Thus, the subcategories of acute Iymphocytic leukemia in humans probably repre sent proliferation of different clones of lymphoblasts. There are known differences in glucocorticoid susceptibility among functional subcategories of lymphocytes in ...
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ژورنال
عنوان ژورنال: CA: A Cancer Journal for Clinicians
سال: 1980
ISSN: 0007-9235
DOI: 10.3322/canjclin.30.3.158